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Home > Products > SYBYL-X

SYBYL-X is NEW!

Fewer mouse clicks.
Faster navigation.
Get right to the heart of the science.
Modeling for molecular discovery and lead optimization.
Lower cost of ownership.
Do more with less.
On Windows or Linux.
Get it today!

SYBYL-X

Computational Informatics Software for Molecular Modelers

Whether you're looking for the next new breakthrough drug, the next generation in pesticides, the most exciting new flavor or fragrance, or any other molecular discovery project, we know what you’re up against. You have enormous pressure to produce results, in a very short period of time.   SYBYL®-X enables processes and decision-making that you control, not a onesize-fits-all confining approach. With SYBYL-x you look at molecular structures and properties in a manner that is designed to:

  • discover and optimize lead candidates
  • save time in your processes
  • smooth and simplify workflows
  • accelerate the pace of discovery
  • lower your cost of ownership

New in SYBYL-X 

The SYBYL-X 1.1 release provides molecular modelers with significant improvements in usability, providing a far more intuitive modeling experience and reducing by half the number of mouse clicks and by more than half the mouse travel needed for basic molecule visualization and manipulation!  Particularly noteworthy enhancements in the new SYBYL-X include: 

  • Enhanced, simplified menu systems for frequently used functions
  • Significantly updated toolbar system
  • A new selection model that simplifies selection of molecules and surfaces
  • Context sensitive (right-click) menus
  • Enhanced session saving capabilities

SYBYL-X Brochure (639K)                  SYBYL System Requirements

Our overall goal for SYBYL-X is to provide you with access to the highest quality and validated scientific techniques, so that application of CADD maximizes your productivity within an increasingly demanding working environment. The SYBYL-X strategy is three-fold:

  • Quick Access - making the basic things quick and easy
  • Workflows - simplifying and streamlining an entire workflow, from data input to presentation of results
  • Scientific Innovation - creating and delivering scientific capabilities that provide the newest and/or best of those methodologies which are most helpful in the design of bioactive molecules.

Leveraging the major infrastructure investments we made in the first release of SYBYL-X, SYBYL-X 1.1 emphasizes Quick Access to make your use of SYBYL-X more efficient and pleasurable. You will notice many improved possibilities for the basic use of SYBYL-X.  Get it today!

  • SYBYL

SYBYL Base

Comprehensive tools for molecular modeling: structure building, optimization, and comparison; visualization of structures and associated data; annotation, hardcopy, and screen capture capabilities; and a wide range of force fields. With its easy-to-use interface, SYBYL Base is fully integrated with SYBYL Applications.

Ligand Based Design

Applications for SAR and ADME, as well as Pharmacophore Perception and Molecular Alignment

Receptor Based Design

Applications for Docking and de novo Design

Structural Biology

Applications for Macromolecular Modeling and Bioinformatics

Library Design

Applications for Library Creation and Molecular Diversity

Cheminformatics

Applications for Data Mining and Structure Representation

Supplemental Technologies

Applications for use in many computational informatics workflows